Wigley F M, Flavahan N A
Division of Rheumatology, Johns Hopkins University, Baltimore, MD 21205, USA.
Rheum Dis Clin North Am. 1996 Nov;22(4):765-81. doi: 10.1016/s0889-857x(05)70300-8.
Raynaud's phenomenon is a common clinical problem occurring in 3% to 5% of the general population. The first symptom of scleroderma is often Raynaud's phenomenon, which is associated with a diffuse small vessel vasculopathy and ischemia and reperfusion injury to skin and other organs targeted in this disease. Current studies support the concept that Raynaud's phenomenon is secondary to a local defect in the regulation of regional blood flow. New evidence demonstrates that there is a profound sensitivity to alpha 2-adrenoceptors mediated vasoconstriction in scleroderma vessels. Traditional treatment of Raynaud's phenomenon is cold avoidance and the use of vasodilators. Oral prostaglandins have shown promise as therapeutic agents.
雷诺现象是一种常见的临床问题，在普通人群中的发生率为3%至5%。硬皮病的首发症状通常是雷诺现象，它与弥漫性小血管血管病变以及该疾病所累及的皮肤和其他器官的缺血及再灌注损伤有关。目前的研究支持这样一种观点，即雷诺现象继发于局部区域血流调节缺陷。新证据表明，硬皮病血管对α2肾上腺素能受体介导的血管收缩具有高度敏感性。雷诺现象的传统治疗方法是避免寒冷和使用血管扩张剂。口服前列腺素已显示出作为治疗药物的前景。
