Freedman R R, Ianni P
Br Med J (Clin Res Ed). 1983 Nov 19;287(6404):1499-502. doi: 10.1136/bmj.287.6404.1499.
Research on the aetiology of Raynaud's disease and phenomenon has been hindered by the difficulty of provoking attacks in the laboratory. A study was therefore conducted in which digital and ambient temperatures, electrocardiograms, and stress ratings were obtained during ambulatory monitoring in patients with idiopathic Raynaud's disease, Raynaud's phenomenon secondary to scleroderma, and in normal subjects. In Raynaud's disease about one third of the vasospastic attacks were associated with tachycardia and increased stress ratings without declines in ambient temperature. In contrast, cold alone was enough to provoke most attacks of Raynaud's phenomenon in scleroderma. Chronically increased stress ratings in patients with scleroderma and increased muscle tension in anticipation of a cold stimulus suggest that these patients have different patterns of stress responses from those with Raynaud's disease.
雷诺病和雷诺现象病因的研究因在实验室中诱发发作困难而受阻。因此进行了一项研究，在特发性雷诺病患者、硬皮病继发的雷诺现象患者以及正常受试者进行动态监测期间，获取手指温度、环境温度、心电图和应激评分。在雷诺病中，约三分之一的血管痉挛发作与心动过速和应激评分增加有关，而环境温度并未下降。相比之下，寒冷本身就足以诱发硬皮病患者的大多数雷诺现象发作。硬皮病患者长期应激评分增加以及在预期寒冷刺激时肌肉紧张度增加，表明这些患者的应激反应模式与雷诺病患者不同。
