Bick R L, Girardi T V, Lack W J, Costa M, Titelbaum D
Department of Haematology (Medicine and Pathology), University of Tasmania School of Medicine, Australia.
Int J Hematol. 1996 Oct;64(3-4):257-62. doi: 10.1016/0925-5710(96)00489-6.
During an epidemiological study assessing cancer risk in a small isolated population exposed to excessive amounts of hexavalent chromium, we noted two patients with Hodgkin's disease after exposure for many years and after a long latency period. The study population demonstrated an observed risk between 65 and 92 times that of reported risks for non-exposed US populations. Although malignant lymphoma, as well as many other malignancies, has clearly been associated with hexavalent chromium exposure, no reports have yet specifically mentioned Hodgkin's disease. We herein report Hodgkin's disease specifically in two individuals so exposed. Although this may be a chance occurrence, clinicians should be aware of the potential association between hexavalent chromium exposure and Hodgkin's lymphoma.
在一项针对一小群接触过量六价铬的孤立人群进行癌症风险评估的流行病学研究中，我们注意到两名患者在接触多年且经过很长潜伏期后患上了霍奇金病。研究人群显示出的观察到的风险是未接触的美国人群报告风险的65至92倍。尽管恶性淋巴瘤以及许多其他恶性肿瘤显然与六价铬接触有关，但尚无报告专门提及霍奇金病。我们在此报告两名如此接触过六价铬的个体患霍奇金病的情况。尽管这可能是偶然发生的，但临床医生应意识到六价铬接触与霍奇金淋巴瘤之间的潜在关联。
