Kubo I, Chaudhuri S K, Kubo Y, Sanchez Y, Ogura T, Saito T, Ishikawa H, Haraguchi H
Department of Environmental Science, Policy and Management, University of California, Berkeley 94720-3112, USA.
Planta Med. 1996 Oct;62(5):427-30. doi: 10.1055/s-2006-957932.
Four sesquiterpenoids, beta-caryophyllene, beta-caryophyllene 4,5 alpha-oxide, 7-hydroxy-3,4-dihydrocadalin, and 7-hydroxycadalin, isolated from the dried flower of Heterotheca inuloides Cass. (Asteraceae), have been found to exhibit cytotoxic activity against several solid tumor cell lines. Among them, 7-hydroxy-3,4-dihydrocadalin and 7-hydroxycadalin have also been found to inhibit autoxidative and microsomal lipid peroxidation.
从异叶泽兰（菊科）干燥花中分离出的四种倍半萜类化合物，即β-石竹烯、β-石竹烯4,5α-氧化物、7-羟基-3,4-二氢卡达林和7-羟基卡达林，已被发现对几种实体瘤细胞系具有细胞毒性活性。其中，7-羟基-3,4-二氢卡达林和7-羟基卡达林还被发现可抑制自氧化和微粒体脂质过氧化。
