Toyota M, Tanimura K, Asakawa Y
Planta Med. 1998 Jun;64(5):462-4. doi: 10.1055/s-2006-957484.
The ether extract of the Japanese liverwort, Plagiochila ovalifolia Mitt. (Plagiochilaceae) yielded three 2,3-secoaromadendrane-type sesquiterpenoids, plagiochiline-A-15-yl octanoate, 14-hydroxyplagiochiline-A-15-yl 2E,4E-dodecadienoate and 14-hydroxyplagiochiline-A-15-yl 2E,4E,8Z-tetradecatrienoate. The two latter compounds were first isolated from the Plagiochila species. The structures of the new compounds were elucidated by spectroscopy. Plagiochiline-A-15-yl octanoate and 14-hydroxyplagiochiline-A-15-yl 2E,4E-dodecadienoate showed significant cytotoxicity against P-388 murine leukemia tumor cells, both compounds exhibiting an ID50 of 0.05 microgram/ml. Plagiochiline A also showed cytotoxic activity. The ID50 was 3.0 micrograms/ml.
日本叶苔Plagiochila ovalifolia Mitt.（叶苔科）的乙醚提取物产生了三种2,3-裂环芳樟烷型倍半萜类化合物，即扁枝石松碱A-15-基辛酸酯、14-羟基扁枝石松碱A-15-基2E,4E-十二碳二烯酸酯和14-羟基扁枝石松碱A-15-基2E,4E,8Z-十四碳三烯酸酯。后两种化合物首次从叶苔属植物中分离得到。通过光谱学方法阐明了新化合物的结构。扁枝石松碱A-15-基辛酸酯和14-羟基扁枝石松碱A-15-基2E,4E-十二碳二烯酸酯对P-388小鼠白血病肿瘤细胞显示出显著的细胞毒性，两种化合物的半数抑制浓度（ID50）均为0.05微克/毫升。扁枝石松碱A也显示出细胞毒性活性，其ID50为3.0微克/毫升。
