Koltin Y
Genetics. 1977 Jul;86(3):527-34. doi: 10.1093/genetics/86.3.527.
Mutants with partial genomes for the virus-like particles of U. maydis were recovered following treatment with nitrosoguanidine. Examination of the properties retained by progeny of genetic crosses indicates that the 2.9 X 10(6) dalton component of double-stranded RNA contains the information for capsid formation and dsRNA replication. Other components appear to contain the information for killer function and immunity to killer. The use of such mutants for studies on the evolution of viruses with segmented genomes is discussed.
在用亚硝基胍处理后,获得了具有黑粉菌病毒样颗粒部分基因组的突变体。对遗传杂交后代所保留特性的研究表明,双链RNA的2.9×10⁶道尔顿组分包含衣壳形成和双链RNA复制的信息。其他组分似乎包含杀伤功能和对杀伤作用免疫的信息。本文还讨论了利用此类突变体研究具有分段基因组的病毒的进化。