具有重叠世代群体中功能上位性和连锁不平衡的模型。
A model of functional epistasis and linkage disequilibrium in populations with overlapping generations.
作者信息
Giesel J T
出版信息
Genetics. 1977 Jul;86(3):679-86. doi: 10.1093/genetics/86.3.679.
A model of functional epistasis is proposed in which it is assumed that coupling and repulsion genotypes differ in metabolic efficiency and thus in development time and net fecundity. The implications of this model are investigated for iteroparous populations with fluctuating rates of increase. It is found that the fluctuations in rate of increase can lead to large fluctuations in gamete frequency and D, the coefficient of linkage disequilibrium, but that D will almost always have a value of zero at some point during the populations' demographic cycle. Some of the model populations would be expected to be in a state of linkage disequilibrium only fleetingly: others would exhibit D-cycles interpretable as random fluctuation. Implications of the model for interpretations of existing data on linkage disequilibrium among enzyme loci in Drosophila are discussed.
提出了一种功能上位性模型，其中假设相引组和相斥组基因型在代谢效率上存在差异，因而在发育时间和净繁殖力上也存在差异。研究了该模型对于具有波动增长率的反复繁殖种群的影响。结果发现，增长率的波动会导致配子频率和连锁不平衡系数D出现大幅波动，但在种群的人口统计学周期中的某个时刻，D几乎总是会为零。预计一些模型种群只会短暂地处于连锁不平衡状态：其他种群则会表现出可解释为随机波动的D周期。讨论了该模型对于解释果蝇酶基因座间现有连锁不平衡数据的意义。
Zotero 插件