Clements D A, Weigle K A, Gilbert G L
Department of Microbiology, Royal Children's Hospital, Parkville, Victoria, Australia.
J Paediatr Child Health. 1995 Dec;31(6):513-8. doi: 10.1111/j.1440-1754.1995.tb00874.x.
To determine whether day-care attendance was a risk factor for Haemophilus influenzae type b (Hib) disease, particularly for epiglottitis.
A case-control analysis of risk factors for invasive Hib disease was performed in Victoria, Australia between February 1988 and February 1990 prior to the introduction of immunization for Hib. A total of 210 cases and 367 day surgery hospital controls were enrolled prospectively. Data were collected by questionnaire at the time of admission.
Logistic regression analysis showed that risk factors for meningitis were day-care attendance, household crowding and recent illness in a sibling. Risk factors for epiglottitis were day-care attendance and mother's birthplace in Australia or New Zealand.
This study confirms that day-care attendance is a risk factor for Hib epiglottitis as well as meningitis. In addition, the mother's birthplace in Australia or New Zealand is a risk factor for epiglottitis in these data. The reason for this latter observation is unclear.
确定日托是否为b型流感嗜血杆菌（Hib）疾病的危险因素，尤其是会厌炎的危险因素。
1988年2月至1990年2月在澳大利亚维多利亚州对侵袭性Hib疾病的危险因素进行了病例对照分析，当时尚未引入Hib疫苗接种。前瞻性纳入了210例病例和367名日间手术医院对照。入院时通过问卷调查收集数据。
逻辑回归分析显示，脑膜炎的危险因素为日托、家庭拥挤和兄弟姐妹近期患病。会厌炎的危险因素为日托以及母亲在澳大利亚或新西兰出生。
本研究证实日托是Hib会厌炎和脑膜炎的危险因素。此外，在这些数据中，母亲在澳大利亚或新西兰出生是会厌炎的危险因素。后一观察结果的原因尚不清楚。
