过氧亚硝酸根与2'-脱氧鸟苷的加合物：4,5-二氢-5-羟基-4-(亚硝基氧基)-2'-脱氧鸟苷。
An adduct between peroxynitrite and 2'-deoxyguanosine: 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine.
作者信息
Douki T, Cadet J, Ames B N
机构信息
Département de Recherche Fondamentale sur la Matière Condensée, SESAM/LAN, Grenoble, France.
出版信息
Chem Res Toxicol. 1996 Jan-Feb;9(1):3-7. doi: 10.1021/tx950126n.
The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4-C5 double bond of 2'-deoxyguanosine with formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine (nox-dG). This adduct may be a useful marker in the study of the chemical processes associated with the mutagenicity of peroxynitrite.
过氧亚硝酸根（OONO⁻）与DNA的反应活性备受关注，因为它是在慢性炎症过程中释放出来的，而慢性炎症是癌症的主要促成因素。研究发现，过氧亚硝酸根会对2'-脱氧鸟苷的C4-C5双键进行均裂加成反应，生成4,5-二氢-5-羟基-4-（亚硝基氧基）-2'-脱氧鸟苷（nox-dG）。这种加合物可能是研究与过氧亚硝酸根致突变性相关化学过程的有用标志物。
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