• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

绿茶多酚对氧化应激引起的肾损伤的保护作用。

Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress.

机构信息

Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.

出版信息

Evid Based Complement Alternat Med. 2012;2012:845917. doi: 10.1155/2012/845917. Epub 2012 Jul 10.

DOI:10.1155/2012/845917
PMID:22844338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3400435/
Abstract

Green tea, prepared from the leaves of Camellia sinensis L., is a beverage that is popular worldwide. Polyphenols in green tea have been receiving much attention as potential compounds for the maintenance of human health due to their varied biological activity and low toxicity. In particular, the contribution of antioxidant activity to the prevention of diseases caused by oxidative stress has been focused upon. Therefore, in this study, we investigated the effects of (-)-epigallocatechin 3-O-gallate and (-)-epigallocatechin 3-O-gallate, which account for a large fraction of the components of green tea polyphenol, on oxidative stress-related renal disease. Our observations suggest that green tea polyphenols have a beneficial effect on pathological states related to oxidative stress of the kidney.

摘要

绿茶是由山茶属植物的叶子制成的一种饮料，在全世界都很受欢迎。由于其具有多种生物活性且毒性低，绿茶中的多酚已作为潜在的维持人类健康的化合物而受到广泛关注。特别是，抗氧化活性对预防由氧化应激引起的疾病的贡献受到了关注。因此，在这项研究中，我们研究了(-)-表没食子儿茶素 3-O-没食子酸酯和(-)-表没食子儿茶素 3-O-没食子酸酯对与氧化应激相关的肾脏疾病的影响，这两种物质占绿茶多酚成分的很大一部分。我们的观察结果表明，绿茶多酚对与肾脏氧化应激相关的病理状态具有有益的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/dc360605ab8d/ECAM2012-845917.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/74a845829780/ECAM2012-845917.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/31c64acc1260/ECAM2012-845917.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/724eea008b5e/ECAM2012-845917.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/b00fb0afc354/ECAM2012-845917.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/af2fd12d84b2/ECAM2012-845917.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/5f7685c82023/ECAM2012-845917.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/cd747011ed26/ECAM2012-845917.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/0d0669301718/ECAM2012-845917.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/a166b19ebfd3/ECAM2012-845917.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/dc360605ab8d/ECAM2012-845917.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/74a845829780/ECAM2012-845917.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/31c64acc1260/ECAM2012-845917.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/724eea008b5e/ECAM2012-845917.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/b00fb0afc354/ECAM2012-845917.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/af2fd12d84b2/ECAM2012-845917.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/5f7685c82023/ECAM2012-845917.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/cd747011ed26/ECAM2012-845917.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/0d0669301718/ECAM2012-845917.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/a166b19ebfd3/ECAM2012-845917.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6515/3400435/dc360605ab8d/ECAM2012-845917.010.jpg

相似文献

1
Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress.绿茶多酚对氧化应激引起的肾损伤的保护作用。
Evid Based Complement Alternat Med. 2012;2012:845917. doi: 10.1155/2012/845917. Epub 2012 Jul 10.
2
Potential anthelmintics: polyphenols from the tea plant Camellia sinensis L. are lethally toxic to Caenorhabditis elegans.潜在的驱虫剂：茶树（Camellia sinensis L.）中的多酚对秀丽隐杆线虫具有致命毒性。
J Nat Med. 2008 Apr;62(2):155-9. doi: 10.1007/s11418-007-0201-4. Epub 2008 Jan 18.
3
Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols.营养因素和烟草制品导致慢性病的机制以及茶多酚对其的预防作用。
Food Chem Toxicol. 2002 Aug;40(8):1145-54. doi: 10.1016/s0278-6915(02)00044-3.
4
Green tea: a promising natural product in oral health.绿茶：口腔健康有前景的天然产物。
Arch Oral Biol. 2012 May;57(5):429-35. doi: 10.1016/j.archoralbio.2011.11.017. Epub 2012 Jan 5.
5
Structural characteristics for superoxide anion radical scavenging and productive activities of green tea polyphenols including proanthocyanidin dimers.包括原花青素二聚体在内的绿茶多酚对超氧阴离子自由基的清除结构特征及生产活性。
Chem Pharm Bull (Tokyo). 2010 Jan;58(1):98-102. doi: 10.1248/cpb.58.98.
6
Green tea: nature's defense against malignancies.绿茶：大自然对抗恶性肿瘤的防御手段。
Crit Rev Food Sci Nutr. 2009 May;49(5):463-73. doi: 10.1080/10408390802145310.
7
Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer.绿茶（茶树）提取物及其在癌症预防中的可能作用。
Altern Med Rev. 1999 Oct;4(5):360-70.
8
Tea Polyphenols in Promotion of Human Health.茶多芬对人体健康的促进作用。
Nutrients. 2018 Dec 25;11(1):39. doi: 10.3390/nu11010039.
9
Effect of green tea powder (Camellia sinensis L. cv. Benifuuki) particle size on O-methylated EGCG absorption in rats; The Kakegawa Study.绿茶粉（Camellia sinensis L. cv. Benifuuki）粒径对大鼠 O-甲基化 EGCG 吸收的影响；香川县研究。
Cytotechnology. 2011 Mar;63(2):171-9. doi: 10.1007/s10616-010-9331-8. Epub 2011 Jan 5.
10
Skin photoprotection by green tea: antioxidant and immunomodulatory effects.绿茶对皮肤的光保护作用：抗氧化和免疫调节作用。
Curr Drug Targets Immune Endocr Metabol Disord. 2003 Sep;3(3):234-42. doi: 10.2174/1568008033340171.

引用本文的文献

1
Larreat (), a Potential Nephroprotector against Oxidative Damage Provoked by STZ-Induced Hyperglycemia in Rats.Larreat（），一种可能对链脲佐菌素诱导的大鼠高血糖引发的氧化损伤具有肾保护作用的物质。
Plants (Basel). 2023 Oct 14;12(20):3572. doi: 10.3390/plants12203572.
2
Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy).内源性和外源性抗氧化剂作为预防造影剂负面影响（造影剂诱发的肾病）的药物。
Pharmaceuticals (Basel). 2023 Jul 28;16(8):1077. doi: 10.3390/ph16081077.
3
A Comprehensive Review on Beneficial Effects of Catechins on Secondary Mitochondrial Diseases.

本文引用的文献

1
Creatinine and HMH (5-hydroxy-1-methylhydantoin, NZ-419) as intrinsic hydroxyl radical scavengers.肌酐和HMH（5-羟基-1-甲基乙内酰脲，NZ-419）作为内源性羟自由基清除剂。
Drug Discov Ther. 2011 Aug;5(4):162-75. doi: 10.5582/ddt.2011.v5.4.162.
2
The green tea polyphenol (-)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis.绿茶多酚 (-)-表没食子儿茶素-3-没食子酸酯可改善实验性免疫介导性肾小球肾炎。
Kidney Int. 2011 Sep;80(6):601-11. doi: 10.1038/ki.2011.121. Epub 2011 May 4.
3
Protective effect of green tea extract on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney.
儿茶素对次级线粒体疾病的有益作用的综合评价。
Int J Mol Sci. 2022 Sep 30;23(19):11569. doi: 10.3390/ijms231911569.
4
Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway.茶多酚通过调节 Keap1/Nrf2/ARE 通路减轻氧化应激诱导的椎间盘退变。
Oxid Med Cell Longev. 2021 Jan 7;2021:6684147. doi: 10.1155/2021/6684147. eCollection 2021.
5
Mechanisms of Herbal Nephroprotection in diabetes mellitus.中草药在糖尿病肾病中的保护机制。
J Diabetes Res. 2020 Jun 30;2020:5710513. doi: 10.1155/2020/5710513. eCollection 2020.
6
Green tea polyphenols protect against preglomerular arteriopathy via the jagged1/notch1 pathway.绿茶多酚通过Jagged1/Notch1信号通路预防肾小体前动脉病变。
Am J Transl Res. 2018 Oct 15;10(10):3276-3290. eCollection 2018.
7
The effect of epigallocatechin-3-gallate on the renal dysfunction in the obstructed kidney in the rat.表没食子儿茶素-3-没食子酸酯对大鼠梗阻性肾病肾功能障碍的影响
Int J Physiol Pathophysiol Pharmacol. 2017 Sep 1;9(4):119-126. eCollection 2017.
8
Renoprotective effects of green tea.绿茶的肾脏保护作用。
J Nephropharmacol. 2013 Jul 1;2(2):21-22. eCollection 2013.
9
Tea polyphenols protect against ischemia/reperfusion-induced liver injury in mice through anti-oxidative and anti-apoptotic properties.茶多酚通过抗氧化和抗凋亡特性保护小鼠免受缺血/再灌注诱导的肝损伤。
Exp Ther Med. 2016 Nov;12(5):3433-3439. doi: 10.3892/etm.2016.3789. Epub 2016 Oct 11.
10
Green tea polyphenols protect spinal cord neurons against hydrogen peroxide-induced oxidative stress.绿茶多酚可保护脊髓神经元免受过氧化氢诱导的氧化应激。
Neural Regen Res. 2014 Jul 15;9(14):1379-85. doi: 10.4103/1673-5374.137591.
绿茶提取物对庆大霉素诱导的大鼠肾毒性及肾氧化损伤的保护作用。
Pharmacol Res. 2009 Apr;59(4):254-62. doi: 10.1016/j.phrs.2008.12.009. Epub 2009 Jan 20.
4
Protection of rabbit kidney from ischemia/reperfusion injury by green tea polyphenol pretreatment.绿茶多酚预处理对兔肾缺血/再灌注损伤的保护作用
Arch Pharm Res. 2007 Nov;30(11):1447-54. doi: 10.1007/BF02977370.
5
Therapeutic potential of (-)-epigallocatechin 3-O-gallate on renal damage in diabetic nephropathy model rats.（-）-表没食子儿茶素-3-O-没食子酸酯对糖尿病肾病模型大鼠肾损伤的治疗潜力
J Pharmacol Exp Ther. 2006 Oct;319(1):228-36. doi: 10.1124/jpet.106.107029. Epub 2006 Jul 11.
6
Activity of (-)-epigallocatechin 3-O-gallate against oxidative stress in rats with adenine-induced renal failure.
J Agric Food Chem. 2004 Apr 7;52(7):2103-7. doi: 10.1021/jf030258j.
7
(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors.（-）-表儿茶素3-O-没食子酸酯通过与其他自由基抑制剂不同的机制减轻与过氧亚硝酸盐产生相关的损伤。
J Pharm Pharmacol. 2004 Feb;56(2):231-9. doi: 10.1211/0022357022601.
8
Direct scavenging of nitric oxide and superoxide by green tea.绿茶对一氧化氮和超氧阴离子的直接清除作用。
Food Chem Toxicol. 2002 Dec;40(12):1745-50. doi: 10.1016/s0278-6915(02)00169-2.
9
Potential of sanguiin H-6 against oxidative damage in renal mitochondria and apoptosis mediated by peroxynitrite in vivo.桑色素H-6对体内肾线粒体氧化损伤及过氧亚硝酸盐介导的细胞凋亡的作用潜力。
Nephron. 2002 Sep;92(1):133-41. doi: 10.1159/000064483.
10
Accumulation of 8-hydroxy-2'-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats.糖尿病大鼠肾脏中8-羟基-2'-脱氧鸟苷的积累及线粒体DNA缺失
Diabetes. 2002 May;51(5):1588-95. doi: 10.2337/diabetes.51.5.1588.