Kimura I, Miyamoto H, Chen F J, Kimura M
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Biol Pharm Bull. 1996 Mar;19(3):384-7. doi: 10.1248/bpb.19.384.
We investigated the influence of the streptozocin (STZ)-diabetic state on the dose-response curves for salivary flow and protein content in saliva stimulated by pilocarpine and noradrenaline in mice. The diabetic state increased the relative weights of parotid and sublingual salivary glands but not the weight of submandibular glands, despite body weight loss. In the dose-response curves, (1) the maximal responses to stimulation with pilocarpine and noradrenaline on salivary flow, and with noradrenaline on protein content in saliva, were depressed by the diabetic state, and (2) the value of the 50% effective dose for salivary flow with pilocarpine, but not with noradrenaline, was decreasingly altered by diabetic mice. These results suggest that xerostomia, one of the complications of non-insulin-dependent diabetes mellitus, is caused in part by muscarinic and adrenergic receptor dysfunction in the salivary glands.
我们研究了链脲佐菌素（STZ）诱导的糖尿病状态对毛果芸香碱和去甲肾上腺素刺激小鼠唾液分泌量及唾液蛋白含量剂量反应曲线的影响。尽管体重减轻，但糖尿病状态增加了腮腺和舌下腺的相对重量，而颌下腺重量未增加。在剂量反应曲线中，（1）糖尿病状态抑制了毛果芸香碱和去甲肾上腺素刺激唾液分泌量以及去甲肾上腺素刺激唾液蛋白含量的最大反应，（2）糖尿病小鼠使毛果芸香碱刺激唾液分泌量的半数有效剂量值降低，而去甲肾上腺素刺激唾液分泌量的半数有效剂量值未受影响。这些结果表明，非胰岛素依赖型糖尿病的并发症之一口干症，部分是由唾液腺毒蕈碱能和肾上腺素能受体功能障碍引起的。
