Kucera E, Benesová O
Ustav pro péci o matku a dítĕ, Praha.
Ceska Gynekol. 1996 Jun;61(3):148-50.
Amoxycillin-clavulanate was used in prophylaxis of infectious complications after abdominal hysterectomy. A group of 29 patients was treated routinely with metronidazol introduced vaginally 2-3 days before surgery. This group was compared with 40 patients who received two perioperative doses of Augmentin intravenously. The incidence of febrile morbidity, urinary tract infection, following antibiotic treatment and pelvic infection were followed in both groups. Patients in the amoxycillin-clavulanic acid group had significantly less infectious morbidity than those in the metronidazol group. The results suggest that antibiotic prophylaxis for abdominal hysterectomy is effective. The prophylactic agent should be bactericide against aerobic and anaerobic bacteria and non-toxic. Amoxycillin-clavulanate (Augmentin) meets all these criteria.
阿莫西林 - 克拉维酸盐用于预防腹式子宫切除术后的感染性并发症。一组29例患者在手术前2 - 3天常规经阴道使用甲硝唑治疗。该组与40例接受围手术期静脉注射两剂奥格门汀的患者进行比较。两组均随访了发热性疾病、抗生素治疗后的尿路感染及盆腔感染的发生率。阿莫西林 - 克拉维酸组的感染性发病率明显低于甲硝唑组。结果表明，腹式子宫切除术的抗生素预防是有效的。预防用药应是对需氧菌和厌氧菌有杀菌作用且无毒的。阿莫西林 - 克拉维酸盐（奥格门汀）符合所有这些标准。
