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多不饱和脂肪酸对基因表达的特定影响。

Specific effects of polyunsaturated fatty acids on gene expression.

作者信息

Baillie R A, Jump D B, Clarke S D

机构信息

Department of Human Ecology, University of Texas, Austin 78712, USA.

出版信息

Curr Opin Lipidol. 1996 Feb;7(1):53-5. doi: 10.1097/00041433-199602000-00012.

DOI:10.1097/00041433-199602000-00012
PMID:8925191
Abstract

Dietary polyunsaturated fatty acids modulate the transcription of numerous proteins including several hepatic lipogenic enzymes. Several lines of evidence indicate that polyunsaturated fatty acids do not regulate the transcription of hepatic lipogenic genes via a peroxisomal proliferator-activated receptor, but the mechanism may involve transcription factors related to the carbohydrate response region.

摘要

膳食多不饱和脂肪酸可调节众多蛋白质的转录,包括几种肝脏脂肪生成酶。多项证据表明,多不饱和脂肪酸并非通过过氧化物酶体增殖物激活受体来调节肝脏脂肪生成基因的转录,但其机制可能涉及与碳水化合物反应区域相关的转录因子。

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Specific effects of polyunsaturated fatty acids on gene expression.多不饱和脂肪酸对基因表达的特定影响。
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Polyunsaturated fatty acid regulation of hepatic gene transcription.多不饱和脂肪酸对肝脏基因转录的调控
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Dietary polyunsaturated fatty acid regulation of gene transcription.膳食多不饱和脂肪酸对基因转录的调控
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Polyunsaturated fatty acid regulation of hepatic gene transcription.多不饱和脂肪酸对肝脏基因转录的调控
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The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors.脂肪酸对基因表达的多维调控:多不饱和脂肪作为营养传感器。
Curr Opin Lipidol. 2004 Feb;15(1):13-8. doi: 10.1097/00041433-200402000-00004.
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Polyunsaturated fatty acids regulate lipogenic and peroxisomal gene expression by independent mechanisms.多不饱和脂肪酸通过独立机制调节脂肪生成和过氧化物酶体基因表达。
Prostaglandins Leukot Essent Fatty Acids. 1997 Jul;57(1):65-9. doi: 10.1016/s0952-3278(97)90494-4.
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Multiple mechanisms for polyunsaturated fatty acid regulation of hepatic gene transcription.
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Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription.非酒精性脂肪变性和脂肪性肝炎。I. 多不饱和脂肪酸调控基因转录的分子机制。
Am J Physiol Gastrointest Liver Physiol. 2001 Oct;281(4):G865-9. doi: 10.1152/ajpgi.2001.281.4.G865.

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