Grace J, Bellus S B, Raulin M L, Herz M I, Priest B L, Brenner V, Donnelly K, Smith P, Gunn S
Buffalo Psychiatric Center, New York 14213, USA.
Psychiatr Serv. 1996 Jan;47(1):41-5. doi: 10.1176/ps.47.1.41.
The long-term effects of a combination of clozapine and psychosocial treatment were evaluated in a sample of treatment-refractory state hospital patients with schizophrenia.
A repeated-measure design was used. Thirty-one patients with schizophrenia received both clozapine and an enhanced psychosocial treatment program. Data were collected at baseline and at one-year, two-year, and three-year follow-ups. Psychiatric symptoms, cognitive functioning, dyskinetic movements, and discharge rate were evaluated.
Significant reductions in psychiatric symptoms and improvement in cognitive functioning were found. Differences in the pattern of reductions in positive and negative symptoms over the course of the study were noted. The majority of subjects improved sufficiently to be discharged.
Clozapine, when combined with psychosocial treatment, is effective for treatment of patients with schizophrenia who are not responsive to other medications.
在一组难治性州立医院的精神分裂症患者样本中，评估氯氮平与心理社会治疗相结合的长期效果。
采用重复测量设计。31名精神分裂症患者接受了氯氮平和强化心理社会治疗项目。在基线以及1年、2年和3年随访时收集数据。评估精神症状、认知功能、运动障碍和出院率。
发现精神症状显著减轻，认知功能有所改善。注意到在研究过程中阳性和阴性症状减轻模式的差异。大多数受试者改善到足以出院。
氯氮平与心理社会治疗相结合，对其他药物无反应的精神分裂症患者有效。
