钴胺素全转钴胺素在需要和不需要维生素B12的原核生物与真核生物中的情况

Holotranscobalamins in B12 and non B12 requiring prokaryotes and eukaryotes.

作者信息

Baker H, de Angelis B, Khalil M, Frank O, Baker E R

机构信息

Department of Preventive Medicine, New Jersey Medical School, Newark 07110, USA.

出版信息

Comp Biochem Physiol B Biochem Mol Biol. 1996 Apr;113(4):707-9. doi: 10.1016/0305-0491(95)02096-9.

DOI:10.1016/0305-0491(95)02096-9

PMID:8925438

Abstract

Transcobalamins, vitamin B12 binding proteins, deliver B12 to cell surface receptors which then permit B12 to cross cell membranes for metabolic use. There is little documentation concerning B12 binding proteins in bacteria and protists. We found that prokaryotes and eukaryotes requiring B12, as well as those protists synthesizing B12, also produce several transcobalamins for functionally transporting B12 similar to humans.

摘要

转钴胺素，即维生素B12结合蛋白，将维生素B12传递至细胞表面受体，随后使维生素B12穿过细胞膜以供代谢使用。关于细菌和原生生物中维生素B12结合蛋白的文献资料很少。我们发现，需要维生素B12的原核生物和真核生物，以及那些合成维生素B12的原生生物，也会产生几种转钴胺素，用于像人类一样功能性地转运维生素B12。