新型维生素C磷酸二酯的合成：稳定性与抗氧化活性
Synthesis of novel vitamin C phosphodiesters: stability and antioxidant activity.
作者信息
Morisaki K, Ozaki S
机构信息
Department of Applied Chemistry, Faculty of Engineering, Ehime University, Japan.
出版信息
Carbohydr Res. 1996 Jun 5;286:123-38. doi: 10.1016/0008-6215(96)00043-2.
A novel series of hybrid L-ascorbic acid (vitamin C) phosphodiesters linked at the C-2 hydroxyl group with other biologically active substances, namely myo-inositol, arbutin, 4-hydroxy-L-proline, and glycolic acid were synthesized, and their thermal stability and reducing activity against free radicals were estimated in vitro. All of the phosphodiesters exhibited high thermal stabilities; however, their antioxidant activities in vitro were generally lower than that of vitamin C.
合成了一系列新型的在C-2羟基处与其他生物活性物质（即肌醇、熊果苷、4-羟基-L-脯氨酸和乙醇酸）相连的L-抗坏血酸（维生素C）磷酸二酯，并在体外评估了它们的热稳定性和对自由基的还原活性。所有磷酸二酯均表现出高的热稳定性；然而，它们在体外的抗氧化活性通常低于维生素C。
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