Zochodne D W, Semmler R T, Ludwin S K, Auer R
Department of Clinical Neurosciences and Pathology, University of Calgary, Alberta, Canada.
Clin Neuropathol. 1996 Mar-Apr;15(2):113-5.
We report 2 patients with acute symmetrical axonal motor and sensory polyneuropathy associated with vasculitis. The clinical presentation in each case was not that of a mononeuritis multiplex. Serial electrophysiological studies in 1 of the patients documented the development of confluent axonal degeneration involving several motor and sensory territories over the same period of time. In both patients the diagnosis of necrotizing vasculitis was established by peripheral nerve biopsy and recovery followed treatment with prednisone and cyclophosphamide. Biopsy of an involved nerve should be routinely sought in unexplained acute axonal polyneuropathies.
我们报告了2例与血管炎相关的急性对称性轴索性运动和感觉性多发性神经病患者。每例患者的临床表现并非多发性单神经炎。其中1例患者的系列电生理研究记录了在同一时期内多个运动和感觉区域出现融合性轴索变性。在这2例患者中，通过周围神经活检确诊为坏死性血管炎，经泼尼松和环磷酰胺治疗后病情好转。对于不明原因的急性轴索性多发性神经病，应常规进行受累神经的活检。
