Solberg H E
Department of Clinical Chemistry, Rikshospitalet, Oslo, Norway.
Comput Methods Programs Biomed. 1995 Dec;48(3):247-56. doi: 10.1016/0169-2607(95)01697-x.
RefVal is a computer program that implements the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. The program performs the following main tasks: graphical display of the distribution of reference values, identification or elimination of outliers, testing of the fit of the distribution to Gaussian shape (coefficients of skewness and kurtosis, Anderson-Darling's test, Cramér-von Mises' test, Kolmogorov-Smirnov's test), non-parametric and parametric estimation of reference limits (fractiles, percentiles). The parametric estimation method is based on a two-stage mathematical transformation of data: (1) Manly's exponential transformation (to remove skewness) and (2) John and Draper's modulus transformation (to adjust for remaining kurtosis). The program exists in different versions. The paper describes two of these: (1) a library of FORTRAN functions and subroutines and (2) a Pascal PC program that runs under MS-DOS.
RefVal是一个计算机程序，它执行国际临床化学联合会关于参考值统计处理的建议。该程序执行以下主要任务：参考值分布的图形显示、异常值的识别或消除、分布与高斯形状拟合的检验（偏度和峰度系数、安德森- Darling检验、克拉默-冯·米塞斯检验、柯尔莫哥洛夫-斯米尔诺夫检验）、参考限的非参数和参数估计（分位数、百分位数）。参数估计方法基于数据的两阶段数学变换：（1）曼利指数变换（消除偏度）和（2）约翰和德雷珀的模量变换（调整剩余峰度）。该程序有不同版本。本文描述其中两个版本：（1）一个FORTRAN函数和子例程库，以及（2）一个在MS-DOS下运行的Pascal PC程序。
