Buchpiguel C A, Roizemblatt S, Pastor E H, Hironaka F H, Cossermelli W
Centro de Medicina Nuclear, Departamento de Radiologia, Faculdade de Medicina da USP, Cx Postal 11136, CEP 05422-970, São Paulo-SP, Brasil.
Eur J Nucl Med. 1996 Feb;23(2):199-203. doi: 10.1007/BF01731845.
To determine the role of scintigraphy in the detection of skeletal and cardiac involvement in dermato- and polymyositis (DM/PM), we studied 30 patients with a confirmed diagnosis of DM/PM (23 females, 7 males; mean age: 35 years). Technetium-99m pyrophosphate (99mTc-PYP) and gallium-67 scans showed similar sensitivity, specificity and accuracy in the detection of skeletal muscle involvement when compared with serum enzymes (70%, 100% and 80%, respectively). Compared with the clinical parameters, 99mTc-PYP showed 70% and 67Ga 65% accuracy. Abnormal PYP cardiac uptake was observed in 57% of patients, whereas abnormal 67Ga cardiac uptake was seen in only 15%. Electrocardiography was abnormal in 40%, rest gated blood pool study in 23%, and chest X-ray in 13%. In conclusion, both 99mTc-PYP and 67Ga can be useful in the detection of the active phase of muscle disease. However, 99mTc-PYP seems to be more effective than 67Ga in the early diagnosis of cardiac involvement.
为确定闪烁扫描法在检测皮肌炎和多肌炎（DM/PM）骨骼及心脏受累情况中的作用，我们研究了30例确诊为DM/PM的患者（23例女性，7例男性；平均年龄：35岁）。与血清酶相比，99m锝焦磷酸盐（99mTc-PYP）和镓-67扫描在检测骨骼肌受累方面显示出相似的敏感性、特异性和准确性（分别为70%、100%和80%）。与临床参数相比，99mTc-PYP的准确率为70%，镓-67为65%。57%的患者观察到PYP心脏摄取异常，而只有15%的患者观察到镓-67心脏摄取异常。心电图异常的占40%，静息门控血池显像异常的占23%，胸部X线异常的占13%。总之，99mTc-PYP和镓-67在检测肌肉疾病的活动期均可能有用。然而，99mTc-PYP在心脏受累的早期诊断中似乎比镓-67更有效。
