Bury T, Dowlati A, Paulus P, Hustinx R, Radermecker M, Rigo P
Pneumology Department, CHU Sart Tilman, B-4000 Liege, Belgium.
Eur J Nucl Med. 1996 Feb;23(2):204-6. doi: 10.1007/BF01731846.
Positron emission tomography (PET) using fluorine-18 deoxyglucose (FDG), showing increased FDG uptake and retention in malignant cells, has been proven useful to differentiate malignant from benign tissue. We undertook a prospective study in 61 patients to compare the accuracy of whole-body FDG PET and conventional imaging (CI) methods for the staging of non-small-cell lung cancer (NSCLC). CI included chest and abdomen computed tomographic scanning and bone scintigraphy. When CI or PET study suggested metastatic disease, confirmation was obtained by biopsy or clinical or radiological follow-up. As compared to CI, PET correctly changed the N stage in 13 patients (21%) and the M stage in six patients (10%). There were three false-positive and no false-negative distant PET findings. Our preliminary results show that whole-body FDG PET can improve the diagnostic accuracy in the staging of NSCLC.
使用氟 - 18脱氧葡萄糖（FDG）的正电子发射断层扫描（PET）显示恶性细胞中FDG摄取和滞留增加，已被证明有助于区分恶性组织和良性组织。我们对61例患者进行了一项前瞻性研究，以比较全身FDG PET和传统成像（CI）方法对非小细胞肺癌（NSCLC）分期的准确性。CI包括胸部和腹部计算机断层扫描以及骨闪烁显像。当CI或PET研究提示有转移性疾病时，通过活检或临床或影像学随访来确诊。与CI相比，PET正确改变了13例患者（21%）的N分期和6例患者（10%）的M分期。PET有3例假阳性结果，无远处转移的假阴性结果。我们的初步结果表明，全身FDG PET可以提高NSCLC分期的诊断准确性。
