Figueroa-Damian R, Villagrana-Zesati R, San Martín-Herrasti J M, Arredondo-Garcia J L
Departamento de Infectología e Inmunología, Instituto Nacional de Perinatología, México, D.F.
Ginecol Obstet Mex. 1996 May;64:214-8.
Traditionally obstetric infections have been treated with combination antimicrobial agents that provide coverage against aerobic and anaerobic bacteria commonly found in these infections. New antibiotics may be a monotherapy alternative for this type of infections. The objective of the study was to compare the efficacy of the agent piperacillin/tazobactam against ampicillin plus gentamicin in the treatment of postcesarean endometritis. By randomized way 14 patients were enrolled in the piperacillin/tazobactam group and 42 in the ampicillin-gentamicin group. A favorable clinical response occurred in 78.6% of piperacillin/tazobactam patients and 88.1% of ampicillin and gentamicin patients (p = NS). There was no statistically significant difference in the times to recovery and days of hospitalization between the two groups. The combination piperacillin/tazobactam did not show advantage towards the standard treatment, so combination antimicrobial agent continue been the optimal approach to the management of obstetric infection.
传统上，产科感染一直采用联合抗菌药物治疗，这些药物可覆盖此类感染中常见的需氧菌和厌氧菌。新型抗生素可能是这类感染的单药治疗替代方案。本研究的目的是比较哌拉西林/他唑巴坦与氨苄西林加庆大霉素治疗剖宫产术后子宫内膜炎的疗效。通过随机分组，14例患者被纳入哌拉西林/他唑巴坦组，42例患者被纳入氨苄西林-庆大霉素组。78.6%的哌拉西林/他唑巴坦组患者和88.1%的氨苄西林和庆大霉素组患者出现了良好的临床反应（p=无统计学意义）。两组之间恢复时间和住院天数无统计学显著差异。哌拉西林/他唑巴坦联合用药对标准治疗未显示出优势，因此联合抗菌药物仍然是产科感染管理的最佳方法。
