Oberbeck R, Schürmeyer T, Hosch W, Jetschmann J U, Schmidt R E, Schedlowski M
Division of Clinical Immunology, Medizinische Hochschule Hannover, Germany.
Horm Metab Res. 1996 Mar;28(3):142-6. doi: 10.1055/s-2007-979147.
It is unknown whether plasma catecholamines have direct physiologic effects on pituitary-adrenocortical secretion in man. Therefore we investigated the effects of epinephrine and norepinephrine on plasma concentrations of adrenocorticotropin (ACTH), beta-endorphin and cortisol. Nineteen healthy male volunteers received infusions of either NaCl, epinephrine (0.10 micrograms/kg/min) or norepinephrine (0.15 micrograms/kg/min) for 20 minutes. 30 min before to 120 min after the infusion blood was continuously drawn to determine plasma levels of epinephrine, norepinephrine, and cortisol. In addition, ACTH and beta-endorphin plasma concentrations were analyzed at 6 time points before, during and after infusion. Infusion of catecholamines increased epinephrine and norepinephrine concentrations in physiological ranges as observed during intense psychological stress or exhausting physical exercise. However, these increases in catecholamine plasma levels neither affected concentrations of POMC-derived hormones nor plasma levels of cortisol. We conclude that in man, physiologic increases in circulating catecholamines have no influence on pituitary-adrenal hormone concentrations.
血浆儿茶酚胺对人体垂体 - 肾上腺皮质分泌是否具有直接的生理作用尚不清楚。因此，我们研究了肾上腺素和去甲肾上腺素对促肾上腺皮质激素（ACTH）、β - 内啡肽和皮质醇血浆浓度的影响。19名健康男性志愿者接受了20分钟的氯化钠、肾上腺素（0.10微克/千克/分钟）或去甲肾上腺素（0.15微克/千克/分钟）输注。在输注前30分钟至输注后120分钟期间，持续采集血液以测定肾上腺素、去甲肾上腺素和皮质醇的血浆水平。此外，在输注前、输注期间和输注后的6个时间点分析ACTH和β - 内啡肽的血浆浓度。儿茶酚胺输注使肾上腺素和去甲肾上腺素浓度升高至生理范围内，这种升高类似于在强烈心理应激或剧烈体育锻炼期间观察到的情况。然而，儿茶酚胺血浆水平的这些升高既不影响源自阿片 - 促黑素 - 皮质素原（POMC）的激素浓度，也不影响皮质醇的血浆水平。我们得出结论，在人体中，循环儿茶酚胺的生理性增加对垂体 - 肾上腺激素浓度没有影响。
