O'Connell W A, Dhand L, Cianciotto N P
Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois 60611, USA.
Infect Immun. 1996 Oct;64(10):4381-4. doi: 10.1128/iai.64.10.4381-4384.1996.
We assessed the ability of Legionella species that have not been associated with disease to infect macrophage-like U937 cells. Two of fourteen species tested exhibited a 50% infective dose that was within I log unit of that of virulent L. pneumophila. Indeed, intracellular CFU of L. jamestowniensis and L. parisiensis increased 100-fold over a 72-h period. These data indicate that additional legionellae can flourish within phagocytes and therefore, can, if given the opportunity, cause disease.
我们评估了与疾病无关的军团菌属感染巨噬细胞样U937细胞的能力。在测试的14个菌种中，有2个菌种的半数感染剂量与强毒嗜肺军团菌的半数感染剂量相差在1个对数单位以内。事实上，在72小时内，詹姆斯敦军团菌和巴黎军团菌的细胞内菌落形成单位增加了100倍。这些数据表明，其他军团菌也能在吞噬细胞内大量繁殖，因此，如果有机会，可能会引发疾病。
