辣椒素对离体猫结肠电慢波的影响。
Effect of capsaicin on electrical slow waves in the isolated cat colon.
作者信息
Anuras S, Christensen J, Templeman D
出版信息
Gut. 1977 Aug;18(8):666-9. doi: 10.1136/gut.18.8.666.
Because of the laxative effect of capsaicin, we examined the effect of that agent on the electromyogram of the isolated cat colon. At a concentration of 10(-4)M, it caused a significant reduction in the frequency of the electrical slow waves in the proximal half of the colon. Frequency fell to its lowest value, 45% of control (P less than 0-001), in the most proximal 10% of the organ below the ileocecal junction, and the effect progressively diminished along the colon. In the distal half of the colon, the change in frequency was not significant. Sectioning of the colon into segments reduced the frequency of the slow waves in the proximal half of the colon, and capsaicin, in a concentration of 10(-4)M, further reduced the frequency in the segments representing the proximal 30% of the colon. This effect of capsaicin is like that reported previously with other laxative agents.
由于辣椒素的泻下作用，我们研究了该药物对离体猫结肠肌电图的影响。在浓度为10⁻⁴M时，它导致结肠近端一半的电慢波频率显著降低。在回盲瓣下方最靠近近端的10%的肠段中，频率降至最低值，为对照值的45%（P<0.001），且该效应沿结肠逐渐减弱。在结肠远端一半，频率变化不显著。将结肠切成段会降低结肠近端一半的慢波频率，而浓度为10⁻⁴M的辣椒素会进一步降低代表结肠近端30%的肠段中的频率。辣椒素的这种作用与先前报道的其他泻药的作用相似。
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