Morton N, Polkey C E, Cox T, Morris R G
Department of Clinical Psychology, Institute of Psychiatry, London, UK.
J Clin Exp Neuropsychol. 1996 Feb;18(1):24-37. doi: 10.1080/01688639608408259.
The effect of filling of the posterior cerebral artery (PCA) on memory performance during the intracarotid sodium amytal test (IAP) was investigated in 57 patients with unilateral temporal epileptic seizure foci under consideration for surgical therapy. Memory functioning was tested following injection of the internal carotid artery contralateral and ipsilateral to the side of seizure focus. In both cases, patients with PCA filling observed using conventional angiography showed a greater memory deficit, although this effect was more robust with contralateral injections. In a subsample of patients with left hemisphere dominance for language, the effect of PCA filling on memory performance was only significant when the right hemisphere was injected. The implications of these findings are discussed in terms of the validity of the IAP test and the different factors that need to be taken into account when interpreting IAP memory performance.
在57例因考虑手术治疗而患有单侧颞叶癫痫发作灶的患者中，研究了颈内动脉注射阿米妥钠试验（IAP）期间大脑后动脉（PCA）充盈对记忆表现的影响。在向癫痫病灶对侧和同侧的颈内动脉注射后，对记忆功能进行了测试。在这两种情况下，使用传统血管造影观察到PCA充盈的患者均表现出更大的记忆缺陷，尽管这种效应在对侧注射时更为明显。在语言功能以左半球占优势的患者亚组中，只有在注射右半球时，PCA充盈对记忆表现的影响才显著。本文根据IAP测试的有效性以及解释IAP记忆表现时需要考虑的不同因素，对这些发现的意义进行了讨论。
