感染人类免疫缺陷病毒的女性宫颈上皮内瘤变治疗后的并发症。

Complications after treatment of cervical intraepithelial neoplasia in women infected with the human immunodeficiency virus.

作者信息

Cuthill S, Maiman M, Fruchter R G, Lopatinsky I, Cheng C C

机构信息

Department of Obstetrics and Gynecology, State University of New York, Brooklyn, NY 11203, USA.

出版信息

J Reprod Med. 1995 Dec;40(12):823-8.

PMID:8926610

Abstract

OBJECTIVE

To compare the frequency of complications after treatment of cervical intraepithelial neoplasia (CIN) in human immunodeficiency virus (HIV)-infected and -seronegative women in an ambulatory setting.

STUDY DESIGN

A retrospective record review of 15 HIV-infected and 44 HIV-negative women treated by laser therapy or cone biopsy and retrospective interviews of 20 HIV-infected and 44 HIV-negative women treated by cryotherapy.

RESULTS

Four of 35 (11%) HIV-infected women had excessive bleeding after laser/cone or cryotherapy as compared to one of 88 (1%) HIV-negative women (odds ratio 11.27, P = .02). After laser/cone therapy, significantly more HIV-infected women (53%) had cervicovaginal infections than did HIV-negative women (18%). A higher prevalence of infection was associated with more severe immunodeficiency.

CONCLUSION

HIV-infected women are vulnerable to complications after treatment of CIN and should be monitored closely.

摘要

目的

比较在门诊环境中，感染人类免疫缺陷病毒（HIV）的女性和血清学阴性女性治疗宫颈上皮内瘤变（CIN）后并发症的发生率。

研究设计

对15名接受激光治疗或锥形活检的感染HIV的女性和44名HIV阴性女性进行回顾性记录审查，并对20名接受冷冻疗法的感染HIV的女性和44名HIV阴性女性进行回顾性访谈。

结果

35名感染HIV的女性中有4名（11%）在激光/锥形切除或冷冻治疗后出现大出血，而88名HIV阴性女性中有1名（1%）出现大出血（比值比11.27，P = 0.02）。激光/锥形切除治疗后，感染HIV的女性（53%）宫颈阴道感染的发生率明显高于HIV阴性女性（18%）。感染发生率较高与更严重的免疫缺陷有关。