Jassem E, Kedzia A, Rek M, Wolska-Goszka L, Szelezyński K
Klinika Chorób Płuc i Gruźlicy AM w Gdańsku.
Med Dosw Mikrobiol. 1996;48(1-2):49-54.
The aim of this study was to assess the occurrence of anaerobic non-sporeforming bacteria upper airways flora in the exacerbation of COPD. Sputum from 35 COPD patients was sent to the laboratory in sterile, filled with CO2 containers and cultured under anaerobic conditions. In all patients bacteriological tests were positive. The most common anaerobic bacteria were as follows: Peptostreptococcus - in 28 pts, Fusobacterium - in 27 pts, Bacteroides - in 26 pts and Prevotella in 24. Less common were: Propionibacterium, Actinomyces, Eubacterium, Porphyromonas and Peptococcus. The susceptibility to most common antimicrobial agents was evaluated. All anaerobic bacteria show a significant sensitivity to amoxicillin either with clavulanic acid or ampicillin with sulbactam. Gram-positive rods were resistant to metronidazole and tinidazole.
本研究的目的是评估慢性阻塞性肺疾病（COPD）急性加重期上呼吸道菌群中厌氧性无芽孢细菌的发生情况。35例COPD患者的痰液被置于无菌、充满二氧化碳的容器中送往实验室，并在厌氧条件下培养。所有患者的细菌学检测均呈阳性。最常见的厌氧菌如下：消化链球菌——28例患者中检出；梭杆菌——27例患者中检出；拟杆菌——26例患者中检出；普雷沃菌——24例患者中检出。较不常见的有：丙酸杆菌、放线菌、真杆菌、卟啉单胞菌和消化球菌。评估了对最常用抗菌药物的敏感性。所有厌氧菌对阿莫西林与克拉维酸或氨苄西林与舒巴坦均表现出显著敏感性。革兰氏阳性杆菌对甲硝唑和替硝唑耐药。
