Ramanathan M
Department of Medicine, Taiping Hospital, Perak.
Med J Malaysia. 1995 Sep;50(3):278-9.
This paper deals with two patients on warfarin in whom the use of topical methylsalicylate preparations led to clinically significant bleeding problems. The first patient required fresh frozen plasma to tide over the crisis while the second patient recovered spontaneously on stopping the warfarin temporarily. The possible mechanisms by which salicylates potentiate the anticoagulant effect of warfarin are briefly outlined.
本文涉及两名正在服用华法林的患者，他们使用局部用的水杨酸甲酯制剂后出现了具有临床意义的出血问题。第一名患者需要输注新鲜冷冻血浆来度过危机，而第二名患者在暂时停用华法林后自行康复。文中简要概述了水杨酸酯增强华法林抗凝作用的可能机制。
