大鼠下丘脑芳基酰胺酶的分布及外源性睾酮的作用。
The distribution of arylamidases in the hypothalamus of rat and the effect of exogenous testosterone.
作者信息
Wenn R V, Kamberi I A
出版信息
Horm Metab Res. 1977 Jul;9(4):285-90. doi: 10.1055/s-0028-1093514.
Arylamidase activities towards specific substrates, the 4-nitroanilides of L-alanine, L-leucine, L-phenylanine, L-tyrosinb L-cystine, L-glutamic acid, and L-glycine, have been investigated in different regions of the hypothalamus of adult, male rat. It was found that the activities with respect to these substrates decreased in the order listed above, in all tissues examined. The arylamidase activity towards L-alamine-4-nitroanilide and L-cystine-bis(4-mitroanilide) was elevated in hypothalamic tissues as compared to the cerebral cortex, but the relatives distribution of the activity towards these two substrates varied in different regions of the hypothalamus. Testosterone caused a decrease in the level of arylamidase activity towards the cystine substrate in all hypothalamic regions, an effect which was found to be dose dependent. The role of hypothalamic arylamidases is discussed.
在成年雄性大鼠下丘脑的不同区域，研究了芳基酰胺酶对特定底物（L-丙氨酸、L-亮氨酸、L-苯丙氨酸、L-酪氨酸、L-胱氨酸、L-谷氨酸和L-甘氨酸的4-硝基苯胺）的活性。发现在所有检测的组织中，这些底物的活性以上述列出的顺序降低。与大脑皮层相比，下丘脑组织中对L-丙氨酸-4-硝基苯胺和L-胱氨酸-双（4-硝基苯胺）的芳基酰胺酶活性升高，但对这两种底物的活性相对分布在下丘脑的不同区域有所不同。睾酮导致所有下丘脑区域中对胱氨酸底物的芳基酰胺酶活性水平降低，发现这种作用是剂量依赖性的。讨论了下丘脑芳基酰胺酶的作用。
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