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[外周闭塞性动脉粥样硬化中的代谢综合征和高脂蛋白(a)血症:2例报告]

[The metabolic syndrome and hyper-Lp(a)-lipoproteinemia in peripheral obliterative atherosclerosis: 2 case reports].

作者信息

Tesić D, Derić M, Ivković-Lazar T, Pantelinac P, Lepsanović L

机构信息

Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Institut za interne bolesti, Medicinski fakultet, Novi Sad.

出版信息

Med Pregl. 1996;49(7-8):313-7.

PMID:8926951
Abstract

One of the characteristics of peripheral vascular disease in diabetic patients is that it occurs at the time of detection of diabetes mellitus. As one of the possible pathogenic mechanisms, in non-smokers, is the sol-called metabolic syndrome (obesity, disorders in regard to metabolism of lipids and carbohydrates and hypertension). Lipoprotein Lp(a) is the most atherogenic among lipoproteins. While data on coronary arterial disease exist, although contradictory, there is a small number of those which document the same for peripheral vascular occlusive disease in diabetics. Two patients, non-smokers, with characteristic constellation of risk factors, are described as possible models for further epidemiologic examinations.

摘要

糖尿病患者外周血管疾病的特点之一是在糖尿病被检测出时就已出现。作为一种可能的致病机制,在不吸烟的人群中,是所谓的代谢综合征(肥胖、脂质和碳水化合物代谢紊乱以及高血压)。脂蛋白Lp(a)是脂蛋白中最具致动脉粥样硬化性的。虽然关于冠状动脉疾病的数据存在,尽管相互矛盾,但仅有少量数据记录了糖尿病患者外周血管闭塞性疾病的相同情况。两名不吸烟且具有特征性危险因素组合的患者被描述为进一步进行流行病学检查的可能模型。

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