van de Wouw A J, Buiting A G, van Boven W P, van der Heul C
Sint Elisabethziekenhuis, Afd. Interne Geneeskunde, Tilburg.
Ned Tijdschr Geneeskd. 1996 Sep 7;140(36):1820-2.
In two men, aged 20 and 23 years, who suffered from fever, jaundice, severe muscle pain and decreased renal function, Weil's syndrome was diagnosed, accompanied by severe rhabdomyolysis. Haemodialysis was needed temporarily in one patient. Leptospirosis is a zoonosis caused by spirochaetes. It is a rare disorder in the Netherlands. In 5-10% of the patients so-called icteric leptospirosis is seen: Weil's syndrome. The diagnosis of Weil's syndrome is supported by the presence of high fever, intense muscle aching and jaundice. Renal involvement is frequent and haemodialysis is sometimes required. The pathogenesis of the tubular necrosis is unclear. Adequate therapy can prevent irreversible renal damage.
在两名分别为20岁和23岁的男性患者中，他们出现发热、黄疸、严重肌肉疼痛和肾功能减退，被诊断为韦尔综合征，并伴有严重横纹肌溶解。其中一名患者需要临时进行血液透析。钩端螺旋体病是一种由螺旋体引起的人畜共患病。在荷兰这是一种罕见疾病。在5%-10%的患者中会出现所谓的黄疸型钩端螺旋体病：韦尔综合征。高热、剧烈肌肉酸痛和黄疸的出现支持韦尔综合征的诊断。肾脏受累很常见，有时需要进行血液透析。肾小管坏死的发病机制尚不清楚。充分的治疗可以预防不可逆的肾损伤。
