Burke W J, Hendricks S E, McArthur-Campbell D, Jacques D, Stull T
Psychopharmacology Research Center, Creighton-Nebraska Department of Psychiatry, University of Nebraska Medical Center, Omaha, USA.
Psychopharmacol Bull. 1996;32(1):27-32.
This study explored serum concentrations of fluoxetine and norfluoxetine in subjects treated under different dosing regimens. Using a placebo-controlled, randomized, double-blind design, we compared 20 mg fluoxetine daily, 60 mg fluoxetine weekly, and a placebo. All subjects had responded positively to a 7-week open-label trial of 20 mg fluoxetine daily. Consistent with numerous attempts to correlate fluoxetine and norfluoxetine blood levels to clinical response, we found no significant relationships between serum concentrations and Hamilton Rating Scale for Depression (HAM-D) scores. Serum concentrations were significantly different among the three treatment groups. Pairing the fact that the serum concentrations of subjects given 60 mg fluoxetine weekly were significantly lower than those given 20 mg daily with the finding that the 60 mg weekly group had lower HAM-D scores suggests that, for stabilized subjects, this nontraditional dosing strategy is at least as effective in treating depression as the standard 20 mg fluoxetine daily treatment.
本研究探讨了接受不同给药方案治疗的受试者中氟西汀和去甲氟西汀的血清浓度。采用安慰剂对照、随机、双盲设计，我们比较了每日20mg氟西汀、每周60mg氟西汀和安慰剂。所有受试者在每日20mg氟西汀的7周开放标签试验中均有积极反应。与众多将氟西汀和去甲氟西汀血药浓度与临床反应相关联的尝试一致，我们发现血清浓度与汉密尔顿抑郁量表（HAM-D）评分之间无显著关系。三个治疗组之间血清浓度存在显著差异。每周给予60mg氟西汀的受试者血清浓度显著低于每日给予20mg氟西汀的受试者，且每周60mg组的HAM-D评分较低，这表明对于病情稳定的受试者，这种非传统给药策略在治疗抑郁症方面至少与标准的每日20mg氟西汀治疗同样有效。
