Murad T M, Swaid S, Pritchett P
Hum Pathol. 1977 Jul;8(4):379-90. doi: 10.1016/s0046-8177(77)80003-8.
This presentation describes criteria that we found most helpful in classifying the various proliferative changes of the breast and in separating papillary carcinoma from other benign papillary lesions. The criteria we used are easily understood and extremely reproducible. The true incidence of benign proliferative changes in fibrocystic disease and the significance of these lesions in later development of cancer were determined by studying 200 randomly selected cases of fibrocystic disease seen at least 10 years earlier. Of the 200 cases of fibrocystic disease, 40 showed intraductal papillomatosis or terminal duct hyperplasia. None of the patients with benign proliferative lesions for whom we have complete follow-up data (up to 14 years) developed cancer. In order to determine the type of proliferating cells in papillary carcinoma and benign proliferative lesions, some of the recently encountered cases were studied by transmission and scanning electron microscopy and histochemistry. Our ultrastructural and histochemical study suggests that both epithelial and myoepithelial cells participate in papillary lesions of the breast.
本报告描述了我们发现的对乳腺各种增生性改变进行分类以及区分乳头状癌与其他良性乳头状病变最有帮助的标准。我们使用的标准易于理解且具有极高的可重复性。通过研究200例至少在10年前就已确诊的随机选择的纤维囊性疾病病例，确定了纤维囊性疾病中良性增生性改变的真实发生率以及这些病变在后续癌症发展中的意义。在这200例纤维囊性疾病病例中，40例表现为导管内乳头状瘤病或终末导管增生。对于我们有完整随访数据（长达14年）的良性增生性病变患者，无一例发生癌症。为了确定乳头状癌和良性增生性病变中增殖细胞的类型，我们对一些近期遇到的病例进行了透射和扫描电子显微镜检查以及组织化学研究。我们的超微结构和组织化学研究表明，上皮细胞和肌上皮细胞均参与乳腺的乳头状病变。
