[流式细胞术在急性白血病患者DNA非整倍体检测中的应用]

[Flow cytometry in the determination of DNA aneuploidy in patients with acute leukemias].

作者信息

Shmarov D A, Kuchma Iu M, Miterev G Iu, Kozinets G I

出版信息

Ter Arkh. 1996;68(7):11-4.

Abstract

Bone marrow cellular DNA content was measured by flow cytometry in 107 adult patients with various types of acute leukemia. DNA-aneuploidy was detected in 28 of 107 patients (26%). In 18 patients with DNA-aneuploidy bone marrow was examined throughout 2-36 months. DNA-flow cytometry of bone marrow allows to determine DNA content in leukemia cells and distinguish hypodiploid, diploid, hyperdiploid and tetraploid DNA clones in patients with acute leukemia. In some cases this method allows monitoring of the minimal residual disease.

摘要

采用流式细胞术对107例不同类型的成年急性白血病患者的骨髓细胞DNA含量进行了检测。107例患者中有28例（26%）检测到DNA非整倍体。对18例DNA非整倍体患者的骨髓进行了长达2 - 36个月的检查。骨髓DNA流式细胞术可测定白血病细胞中的DNA含量，并区分急性白血病患者的亚二倍体、二倍体、超二倍体和四倍体DNA克隆。在某些情况下，该方法可用于监测微小残留病。

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