Hultcrantz M
Department of Otorhinolaryngology, Karolinska Hospital, Stockholm, Sweden.
Acta Otolaryngol. 1995 Sep;115(5):638-42. doi: 10.3109/00016489509139379.
Pregnant mice were irradiated with 0.5 and 2 Gy on the 13th gestational day. Offspring were raised until sexual maturity at 2 months of age. Mice from prenatally irradiated mothers and unexposed fathers, or from prenatally irradiated fathers and unexposed mothers, or from parents who had both been prenatally irradiated were mated, resulting in the birth of several mice. These second generation mice were tested as adults for hearing thresholds, with the ABR technique, subjectively to balance tests. and investigated morphologically. Hearing levels were found to be normal and the organ of Corti showed only minor changes of its inner and outer hair cells as shown by transmission and scanning electron microscopy. It is concluded that prenatal irradiation does not seem to cause mutations leading to impaired hearing and balance in second generation mice.
在妊娠第13天，对怀孕小鼠进行0.5 Gy和2 Gy的辐照。子代饲养至2个月龄性成熟。将产前受辐照母亲和未受辐照父亲的子代、或产前受辐照父亲和未受辐照母亲的子代、或父母双方均在产前受辐照的子代进行交配，产下了几只小鼠。这些第二代小鼠成年后采用听性脑干反应（ABR）技术测试听力阈值，进行主观平衡测试，并进行形态学研究。结果发现听力水平正常，透射电子显微镜和扫描电子显微镜显示，柯蒂氏器的内、外毛细胞仅出现轻微变化。结论是，产前辐照似乎不会导致第二代小鼠发生导致听力和平衡受损的突变。
