Yura K, Mori N, Nario K, Sakai S
Department of Otolaryngology, Kagawa Medical School, Japan.
Acta Otolaryngol. 1995 Sep;115(5):648-52. doi: 10.3109/00016489509139381.
The effect of canrenoate, an aldosterone antagonist, on the ampullar endolymphatic potential (AEP) was examined to assess a possible role for aldosterone in the ampulla. Intravenous administration of canrenoate increased the AEP amplitude in a dose-dependent manner, with a significant reduction of the AEP negative component induced by anoxia. Pretreatment with aldosterone attenuated the AEP change produced by canrenoate. The results suggest that aldosterone may be involved in the modulation of ampullar function.
为评估醛固酮在壶腹中可能发挥的作用，研究了醛固酮拮抗剂坎利酸钾对壶腹内淋巴电位（AEP）的影响。静脉注射坎利酸钾可使AEP幅度呈剂量依赖性增加，同时显著降低缺氧诱导的AEP负向成分。醛固酮预处理可减弱坎利酸钾引起的AEP变化。结果表明，醛固酮可能参与壶腹功能的调节。
