Qvarnberg Y, Valtonen H
Department of Otorhinolaryngology-Head and Neck Surgery, Central Hospital of Central Finland, Jyväkylä.
Acta Otolaryngol. 1995 Sep;115(5):653-7. doi: 10.3109/00016489509139382.
During the 10-year period, 1983-92, altogether 7,411 ears of 5,291 children with recurrent or chronic otitis media problems were treated with tympanostomy at our hospital in central Finland, The series was divided into three groups: i) infants aged 6-12 months undergoing primary tube treatment. ii) children aged 1 year or more receiving their first ventilation tube(s) in connection with adenoidectomy, and iii) children who had already had ventilation tubes inserted at least once before the present tympanostomy. Middle ear effusion (MEE) samples were obtained from 4,769 (64.3%) of the affected ears, 69.5% of all MEE cultures were negative for bacteria, whereas 20.2% grew pathogenic bacteria. S. pneumoniae was the most frequent pathogen in group 1, whereas H. influenzae was more frequent than S. pneumoniae in groups 2 and 3. In only 3.7% of MEE cultures were beta-lactamase-producing strains of pathogenic bacteria found, either H. influenzae (0.9%) or M. catarrhalis (2.8%). Comparison of the first and second 5-year periods ( 1983-87 vs. 1988-92) showed no significant changes in the occurrence of the various pathogenic bacteria. An increase was observed in beta-lactamase production for M. catarrhalis but not for H. influenzae strains.
在1983年至1992年这10年期间，芬兰中部我们医院对5291名患有复发性或慢性中耳炎问题的儿童共7411只耳朵进行了鼓膜造孔术治疗。该系列分为三组：i）6至12个月大接受初次置管治疗的婴儿；ii）1岁及以上在腺样体切除术中首次置入通气管的儿童；iii）在本次鼓膜造孔术之前已至少置入过一次通气管的儿童。从4769只（64.3%）患耳获取了中耳积液（MEE）样本，所有MEE培养物中69.5%细菌培养呈阴性，而20.2%培养出致病细菌。肺炎链球菌是第1组中最常见的病原体，而在第2组和第3组中流感嗜血杆菌比肺炎链球菌更常见。在仅3.7%的MEE培养物中发现了产生β-内酰胺酶的致病菌株，即流感嗜血杆菌（0.9%）或卡他莫拉菌（2.8%）。对第一个和第二个5年期间（1983 - 1987年与1988 - 1992年）进行比较，结果显示各种致病细菌的发生率没有显著变化。观察到卡他莫拉菌的β-内酰胺酶产生有所增加，但流感嗜血杆菌菌株没有。
