Bussi M, Carlevato M T, Majore L, Battaglio S, Napoli P, Cortesina G
Il Clinica ORL, Università di Torino.
Acta Otorhinolaryngol Ital. 1995 Apr;15(2):101-6.
Recurrent nasal polyposis is one of the most common unsolved problem in clinical rhinology. In the last few years a great number of histopathological, immunohistochemical and immunological studies on nasal polyps have been carried out by several Authors. Notwithstanding this, the aetiology of these formations still remains unknown. Many data suggest that the presence of polyps is the result of various inflammatory, allergic and pseudo-allergic processes which finally lead to the formation of the oedema constitutive of the polyp itself. In the present report a preliminary trial was carried out in order to evaluate the possibility of preventing recurrences by means of a locally administered anti-H1 receptors drug (Azelastine HCl). In the reported first phase of the study 10 allergic patients with bilateral polyposis were evaluated. Attention was given to the anti-edemigen activity of the drug, as well as to its influence on the local production of Secretory IgA, 7SIgA and albumines. Data are presented and discussed.
复发性鼻息肉是临床鼻科学中最常见的未解决问题之一。在过去几年里，多位作者对鼻息肉进行了大量的组织病理学、免疫组织化学和免疫学研究。尽管如此，这些肿物的病因仍然不明。许多数据表明，息肉的存在是各种炎症、过敏和假过敏过程的结果，最终导致构成息肉本身的水肿形成。在本报告中，进行了一项初步试验，以评估通过局部应用抗H1受体药物（盐酸氮卓斯汀）预防复发的可能性。在该研究报告的第一阶段，对10例双侧息肉病过敏患者进行了评估。关注了该药物的抗水肿活性及其对局部分泌型IgA、7SIgA和白蛋白产生的影响。数据已列出并进行了讨论。
