Cocquyt V, Pipeleers-Marichal M, Delvaux G, Van Belle S
Department of Medical Oncology, University Hospital Gent, Belgium.
Am J Clin Oncol. 1996 Oct;19(5):465-8. doi: 10.1097/00000421-199610000-00008.
Alpha-fetoprotein (AFP) is a useful serum tumor marker especially for hepatocellular carcinoma and yolk-sac tumor. Increased serum levels of AFP have also been found in adenocarcinoma of the stomach, the pancreas, the colon and the lung, and in some squamous cell carcinomas of the lung. We describe a patient with a recurrent gallbladder carcinoma, presenting with increasing serum levels of AFP as the tumor progresses. Remarkable are the histologic changes in the metastases of the tumor, which showed more dedifferentiation as the number of cells containing AFP increased.
甲胎蛋白（AFP）是一种有用的血清肿瘤标志物，尤其对于肝细胞癌和卵黄囊瘤。在胃癌、胰腺癌、结肠癌和肺癌的腺癌以及一些肺鳞状细胞癌中也发现血清AFP水平升高。我们描述了一名复发性胆囊癌患者，随着肿瘤进展，其血清AFP水平不断升高。值得注意的是肿瘤转移灶的组织学变化，随着含AFP细胞数量的增加，转移灶显示出更多的去分化现象。
