St Laurent M, Esterl R M, Halff G A, Speeg K V
Department of Surgery, University of Texas Health Science Center at San Antonio, 78284, USA.
J Clin Gastroenterol. 1999 Mar;28(2):155-8. doi: 10.1097/00004836-199903000-00015.
Alpha-feto protein (AFP) is a clinically useful marker for hepatocellular carcinoma, hepatoblastoma, and nonseminomatous testicular tumors. Elevated serum AFP can also occur with tumors of the gastrointestinal tract, pancreas, lung, kidney, and urachus. Serum AFP can also be minimally elevated in nonmalignant conditions including acute and chronic hepatitis, cirrhosis, and pregnancy. Reports of gallbladder carcinoma that elaborate AFP are extremely rare, and almost all represent papillary carcinomas. Until now, there have been only two reports in the world literature that describe undifferentiated gallbladder carcinoma with elevated serum AFP. The authors present one case of undifferentiated gallbladder carcinoma and another case of poorly differentiated gallbladder carcinoma with increased serum AFP. In both cases, serum AFP was particularly useful in documenting metastatic recurrence of gallbladder carcinoma.
甲胎蛋白（AFP）是肝细胞癌、肝母细胞瘤和非精原细胞瘤性睾丸肿瘤临床上有用的标志物。血清AFP升高也可发生于胃肠道、胰腺、肺、肾和脐尿管肿瘤。在包括急慢性肝炎、肝硬化和妊娠在内的非恶性疾病中，血清AFP也可轻度升高。详细阐述AFP的胆囊癌报告极为罕见，几乎均为乳头状癌。迄今为止，世界文献中仅有两篇报道描述血清AFP升高的未分化胆囊癌。作者报告了1例未分化胆囊癌和另1例血清AFP升高的低分化胆囊癌。在这两例中，血清AFP在记录胆囊癌转移复发方面特别有用。
