Walker W A, Isselbacher K J, Bloch K J
Science. 1972 Aug 18;177(4049):608-10. doi: 10.1126/science.177.4049.608.
Animals were orally immunized with horseradish peroxidase and bovine serum albumin, and absorption of these antigens was studied. In comparison with controls, a consistent and significant decrease in peroxidase uptake was noted in both germ-free and conventional rats immunized with peroxidase; a similar decrease in serum albumin uptake was also noted in animals immunized with serum albumin. There was no difference in the uptake of an unrelated macromolecule. These observations suggest that local immunization interferes specifically with the intestinal uptake of macromolecular antigens.
用辣根过氧化物酶和牛血清白蛋白对动物进行口服免疫，并研究这些抗原的吸收情况。与对照组相比，在用过氧化物酶免疫的无菌和常规大鼠中，过氧化物酶摄取量均持续且显著降低；在用血清白蛋白免疫的动物中，血清白蛋白摄取量也有类似降低。无关大分子的摄取没有差异。这些观察结果表明，局部免疫会特异性干扰肠道对大分子抗原的摄取。
