Volchenko N N, Litvinova L V, Pugachev K K, Shimbireva I B, Kalashnikov V V, Frank G A
Arkh Patol. 1996 Jan-Feb;58(1):6-10.
Mammary carcinoma (MC) of various histological structure are studied immunomorphologically. Positive reaction with proliferative cells nuclear antigen (PCNA) oncoprotein cerbB-2, carcinoembryonic antigen (CEA), trophoblastic beta 1 globulin (TBG) and tissue protein ferritin (Fe) was observed in one third, and with cyprein in half of MC cases. Clear-cut dependence of immunomorphological parameters upon histologic structure and degree of malignancy was not established. An increase of PCNA content with the tumor size increase was observed. There is a tendency to more frequent observation of CEA, Fe, TBG in the presence of the lymph nodes metastases. Most unfavourable for the prognosis are combinations of positive reactions of CEA with TBG, CEA with OCNA, CEA with cerbB-2 as well as PCNA, cerbB-2, CEA.
对各种组织学结构的乳腺癌（MC）进行了免疫形态学研究。在三分之一的MC病例中观察到与增殖细胞核抗原（PCNA）、癌蛋白cerbB - 2、癌胚抗原（CEA）、滋养层β1球蛋白（TBG）和组织蛋白铁蛋白（Fe）呈阳性反应，在一半的MC病例中观察到与鱼精蛋白呈阳性反应。未确定免疫形态学参数与组织结构和恶性程度之间存在明确的相关性。观察到PCNA含量随肿瘤大小增加而增加。在存在淋巴结转移的情况下，CEA、Fe、TBG更常被观察到。对预后最不利的是CEA与TBG、CEA与OCNA、CEA与cerbB - 2以及PCNA、cerbB - 2、CEA的阳性反应组合。
