Fossati A, Vimercati M G, Caputo R, Valenti M
Department of Pharmacology, Farmaceutici Formenti S.p.A., Research Centre, Origgio, VA, Italy.
Arzneimittelforschung. 1995 Nov;45(11):1188-93.
Dextrorphan (CAS 125-73-5) is the active metabolite of the antitussive agent dextromethorphan (CAS 125-71-3). The activity of dextromethorphan, its specific pharmacology, acute toxicity and general pharmacology in respect to the central nervous system were investigated in comparison to dextromethorphan. The studies showed that dextrorphan exerts an antitussive activity comparable to the one of dextromethorphan, but a better tolerability and a lower toxicity. These results suggest to use dextrorphan instead of its precursor dextromethorphan in therapy.
右啡烷（CAS 125-73-5）是镇咳药右美沙芬（CAS 125-71-3）的活性代谢产物。与右美沙芬相比，对右美沙芬的活性、其特定药理学、急性毒性以及关于中枢神经系统的一般药理学进行了研究。研究表明，右啡烷发挥出与右美沙芬相当的镇咳活性，但耐受性更好且毒性更低。这些结果表明在治疗中应使用右啡烷而非其前体右美沙芬。
