2-吡啶基-2-硫代苯并恶唑和2-吡啶基-2-硫代苯并咪唑衍生物对花生四烯酸代谢的合成及抑制作用
Synthesis and inhibitory effects of 2-pyridyl-2-thiobenzoxazole and 2-pyridyl-2-thiobenzimidazole derivatives on arachidonic acid metabolism.
作者信息
Lagorce J F, Fatimi J, Lakhdar M, Chabernaud M L, Buxeraud J, Raby C
机构信息
Department of Organic and Therapeutic Chemistry, Faculty of Pharmacy, University of Limoges, France.
出版信息
Arzneimittelforschung. 1995 Nov;45(11):1207-10.
PMID:8929241
Abstract
A series of new 2-pyridyl-2-thiobenzoxazole and 2-pyridyl-2-thiobenzimidazole compounds was prepared and investigated by a number of in vitro methods in order to determine their prostaglandin synthesis inhibitory activity. The most active compound decreases prostaglandin production and carrageenin edema, but has a less platelet antiaggregatory activity.
摘要
制备了一系列新的2-吡啶基-2-硫代苯并恶唑和2-吡啶基-2-硫代苯并咪唑化合物，并通过多种体外方法进行研究，以确定它们的前列腺素合成抑制活性。活性最高的化合物可减少前列腺素的产生和角叉菜胶性水肿，但血小板抗聚集活性较低。
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