Watson A L, Palmer M E, Burton G J
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
Cell Tissue Res. 1996 Dec;286(3):431-8. doi: 10.1007/s004410050712.
The placenta operates as a vital interface between the mother and fetus. In addition to facilitating fetal nourishment, it acts as a barrier both to potentially deleterious agents and to contact between their two immune systems. As a consequence, damage to the placenta, even on a relatively small scale, could be very dangerous to the fetus. Therefore, wound repair mechanisms are likely to be of great importance in ensuring that an intact placental barrier is re-established as soon as possible. By use of an in vitro method for injuring and subsequently culturing small pieces of first trimester villous tissue, we have observed a number of indications that a wound response is initiated. Pronounced expression of transforming growth factor-beta1, heavy infiltration of macrophages and late deposition of tenascin in the region of the wound all provide good evidence of some form of healing activity. Furthermore, we have noted that these indicators are suggestive of 'adult-type' rather than 'fetal-type' repair processes.
胎盘是母体与胎儿之间至关重要的界面。除了促进胎儿营养供应外，它还作为一道屏障，既能阻挡潜在的有害物质，又能防止母体和胎儿两个免疫系统相互接触。因此，即使胎盘受到相对较小规模的损伤，对胎儿来说也可能非常危险。所以，伤口修复机制对于确保尽快重新建立完整的胎盘屏障可能极为重要。通过使用一种体外方法损伤并随后培养孕早期绒毛组织小块，我们观察到了一些表明伤口反应已启动的迹象。伤口区域转化生长因子-β1 的显著表达、巨噬细胞的大量浸润以及腱生蛋白的晚期沉积，都为某种形式的愈合活动提供了有力证据。此外，我们还注意到这些指标提示的是“成人型”而非“胎儿型”修复过程。
