Kauma S, Matt D, Strom S, Eierman D, Turner T
Department of Obstetrics and Gynecology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
Am J Obstet Gynecol. 1990 Nov;163(5 Pt 1):1430-7. doi: 10.1016/0002-9378(90)90601-3.
Maternal immune recognition of the fetal semiallograft appears to be necessary and beneficial for fetal survival and growth. Interleukin-1 beta and human leukocyte antigen HLA-DR are important for foreign antigen recognition by the immune system, whereas transforming growth factor-beta inhibits many of the immunostimulatory properties of interleukin-1 beta. In this study we found that first-trimester decidua and term placental membranes expressed significantly higher levels of interleukin-1 beta, interleukin-1 beta messenger ribonucleic acid, and human leukocyte antigen HLA-DR alpha messenger ribonucleic acid expression. All tissues found at the maternal-fetal interface, including first-trimester decidua, placenta, and placental membranes, contained transforming growth factor-beta and expressed transforming growth factor-beta 1 messenger ribonucleic acid. On the basis of these findings, we suggest that the increase in decidual interleukin-1 beta and human leukocyte antigen HLA-DR alpha during pregnancy may be involved in maternal recognition of the fetal semiallograft and that transforming growth factor-beta production may regulate the local maternal immune response and prevent rejection of the fetus.
母体对胎儿半同种异体移植物的免疫识别似乎对胎儿的存活和生长是必要且有益的。白细胞介素-1β和人类白细胞抗原HLA-DR对于免疫系统识别外来抗原很重要，而转化生长因子-β会抑制白细胞介素-1β的许多免疫刺激特性。在本研究中，我们发现孕早期蜕膜和足月胎盘膜中白细胞介素-1β、白细胞介素-1β信使核糖核酸以及人类白细胞抗原HLA-DRα信使核糖核酸的表达水平显著更高。在母胎界面发现的所有组织，包括孕早期蜕膜、胎盘和胎盘膜，都含有转化生长因子-β并表达转化生长因子-β1信使核糖核酸。基于这些发现，我们认为孕期蜕膜白细胞介素-1β和人类白细胞抗原HLA-DRα的增加可能参与母体对胎儿半同种异体移植物的识别，并且转化生长因子-β的产生可能调节局部母体免疫反应并防止胎儿被排斥。
