HIV-1感染中的T细胞端粒长度：无证据表明CD4+ T细胞周转率增加。

T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover.

作者信息

Wolthers K C, Bea G, Wisman A, Otto S A, de Roda Husman A M, Schaft N, de Wolf F, Goudsmit J, Coutinho R A, van der Zee A G, Meyaard L, Miedema F

机构信息

Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.

出版信息

Science. 1996 Nov 29;274(5292):1543-7. doi: 10.1126/science.274.5292.1543.

DOI:10.1126/science.274.5292.1543

PMID:8929418

Abstract

Progression to acquired immunodeficiency syndrome (AIDS) has been related to exhaustion of the regenerative capacity of the immune system resulting from high T cell turnover. Analysis of telomeric terminal restriction fragment (TRF) length, a marker for cellular replicative history, showed that CD8(+) T cell TRF length decreased but CD4(+) T cell TRF length was stable during the course of human immunodeficiency virus type-1 (HIV-1) infection, which was not explained by differential telomerase activity. This observation provides evidence that turnover in the course of HIV-1 infection can be increased considerably in CD8(+) T cells, but not in CD4(+) T cells. These results are compatible with CD4(+) T cell decline in HIV-1 infection caused by interference with cell renewal.

摘要

获得性免疫缺陷综合征（AIDS）的进展与高T细胞周转率导致的免疫系统再生能力耗竭有关。对端粒末端限制片段（TRF）长度（一种细胞复制历史的标志物）的分析表明，在人类免疫缺陷病毒1型（HIV-1）感染过程中，CD8(+) T细胞的TRF长度缩短，而CD4(+) T细胞的TRF长度保持稳定，这不能用端粒酶活性差异来解释。这一观察结果证明，在HIV-1感染过程中，CD8(+) T细胞的周转率可大幅增加，而CD4(+) T细胞则不然。这些结果与HIV-1感染中因细胞更新受干扰导致CD4(+) T细胞减少的情况相符。