Dai K S, Chu L C, Liu C Y, Yang P C, Chen S P, Mao S J
Department of Comparative Medicine, Pig Research Institute Taiwan.
J Submicrosc Cytol Pathol. 1996 Jan;28(1):81-5.
A comparison of the collagen network in three dimensions was conducted in 8 hypertrophic cardiomyopathy (HCM)-affected and 8 normal hearts. All these hearts were obtained from male and age-matched pigs of the same breeding farm under identical feeding conditions. The selection of HCM-affected heart was based on the abnormal histologic features such as marked disorientation of muscle cells, thickening of the intramural coronary arterial wall with a narrowed lumen, endocardial fibrosis, and myocardial fibrosis. Mean values of heart weight and ratio of heart to body weight of HCM group were significantly (p < 0.01) increased by 36% and 47%, respectively, but not the body weight, as compared to those of the normal group. The scanning electron microscopic (SEM) investigation demonstrated that collagen weave, struts, and strands appeared more numerous in HCM-affected myocardium than in normals. Moreover, the tendons of collagen in HCM-affected myocardium showed increases in both numbers and thickness.
对8例肥厚型心肌病（HCM）患者和8例正常心脏的三维胶原网络进行了比较。所有这些心脏均取自同一养殖场的雄性且年龄匹配的猪，饲养条件相同。选择受HCM影响的心脏是基于异常的组织学特征，如肌细胞明显排列紊乱、壁内冠状动脉壁增厚伴管腔狭窄、心内膜纤维化和心肌纤维化。与正常组相比，HCM组的心脏重量平均值和心脏与体重之比分别显著增加（p < 0.01）36%和47%，但体重未增加。扫描电子显微镜（SEM）研究表明，与正常心肌相比，受HCM影响的心肌中的胶原编织、支柱和束状结构更多。此外，受HCM影响的心肌中的胶原束在数量和厚度上均有所增加。
