Ishida S, Noda M, Kuzuya N, Kubo F, Yamada S, Yamanaka T, Isozaki O, Hizuka N, Kanazawa Y
Department of Integrated Medicine, Omiya Medical Center, Jichi Medical School.
Intern Med. 1995 Dec;34(12):1201-6. doi: 10.2169/internalmedicine.34.1201.
A 76-year-old female with a hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) was hospitalized because of fasting hypoglycemia. Her sera contained a low concentration of immunoreactive insulin and insulin-like growth factor (IGF)-I, while the IGF-II level was normal. However, most of the IGF-II consisted of the high molecular weight form (big IGF-II). The tumor tissue contained fetal type of IGF-II mRNA (6.0 kb). Furthermore, we found that one of the four patients examined with HCV-related HCC had big IGF-II in serum. This indicates that non-islet cell tumor hypoglycemia (NICTH) in HCV-related HCC might be accompanied by production of big IGF-II by the tumor.
一名患有丙型肝炎病毒（HCV）相关肝细胞癌（HCC）的76岁女性因空腹低血糖症住院。她的血清中免疫反应性胰岛素和胰岛素样生长因子（IGF）-I浓度较低，而IGF-II水平正常。然而，大部分IGF-II由高分子量形式（大IGF-II）组成。肿瘤组织含有胎儿型IGF-II mRNA（6.0 kb）。此外，我们发现，在四名接受检查的HCV相关HCC患者中，有一人血清中存在大IGF-II。这表明，HCV相关HCC中的非胰岛细胞瘤低血糖症（NICTH）可能与肿瘤产生大IGF-II有关。
