Reimann I R, Karpinsky C, Hoffmann A
Institute of Clinical Pharmacology, Friedrich-Schiller-University, Jena, Germany.
Int J Clin Pharmacol Ther. 1996 Feb;34(2):80-3.
An international collaborative WHO-study on drug use in pregnancy of 1987 involving 300 puerperae from Thuringia, East Germany (the former GDR), has partly shown great differences in drug use habits between the countries which had participated on the study. In 1993--after the radical change on the socioeconomic situation in East Germany by the reunification of Germany leading also to changes in health service--an update of the East German data was carried out by repeating the investigation in the same Thuringian region as in 1987. Whereas drug therapy of chronic diseases in pregnancy and drug administration under delivery were widely similar in both investigations, we found a marked increase in drug use in case of illness in the course of pregnancy before admission to hospital for delivery but also in the treatment of nursing women. The differences can be partly put down to socioeconomic development. Because of the continuously enlarging drug market on the one hand and a small data basis on drug risks and side-effects for unborn life on the other hand, a large screening on drug exposition in pregnancy including recording of newborns' data ought to be performed.
1987年，世界卫生组织开展了一项关于孕期药物使用的国际合作研究，涉及来自东德图林根州（前德意志民主共和国）的300名产妇，该研究部分显示了参与研究的国家之间在药物使用习惯上存在巨大差异。1993年——德国统一导致东德社会经济状况发生根本性变化，同时也带来了医疗服务的变革——在与1987年相同的图林根地区重复进行调查，对东德的数据进行了更新。尽管两项调查中孕期慢性病的药物治疗和分娩时的药物给药情况大致相似，但我们发现，在入院分娩前的孕期患病情况下以及在哺乳期妇女的治疗中，药物使用显著增加。这些差异部分可归因于社会经济发展。一方面，由于药物市场不断扩大，另一方面，关于药物对未出生生命的风险和副作用的数据基础较小，因此应该对孕期药物暴露情况进行大规模筛查，包括记录新生儿的数据。
